Fresh analysis suggests that people who stop using new GLP-1 drugs like Wegovy and Mounjaro may regain shed pounds far faster than those who halt traditional lifestyle plans.
Findings released in a major medical journal points out that while obese individuals can lose about a fifth of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month after stopping.
"People using such treatments need to be aware of the potential of fast weight regain when the therapy ends," stated expert Dr. Susan Jebb.
Such speed of regain implies a reversion to starting weight in about a year and a half.
Weighing Treatments
The study, which reviewed dozens of trials involving thousands of patients, compared the results of these new drugs with other pills.
The team point out that individuals who shed pounds through lifestyle changes alone generally see a less rapid weight regain—approximately 100 grams monthly—once they finish.
Explaining the Quick Rebound
Doctors propose the way of the drugs explains the amplified weight return.
GLP-1 drugs copy a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 levels far above than normal could lead to the system to produce less of its own natural GLP-1, and could diminish responsiveness to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this hormone supplement results in appetite is no longer kept in check, making excessive eating a significant risk."
A Lifelong Condition?
Health authorities suggest the jabs for individuals with weight-linked medical conditions, alongside prescribed lifestyle changes.
Professionals argue that, considering the significant potential of weight regain, the treatment is often long-term.
This opinion is echoed by drug manufacturers, who state that the results "underscore the chronic character of excess weight," akin to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have come off the jabs describe a intense resurgence of hunger.
"It felt as if a switch that goes on and you're instantly ravenous," said one woman.
This difficulty is exacerbated if patients have not established lasting lifestyle or habit modifications during treatment.
Significant Use
Recent estimates indicate that millions of adults in the UK have used these injections in the last 12 months, with desire being substantial.
- Adoption is higher among women compared to males.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the drugs through private healthcare rather than the NHS.
In conclusion, researchers caution that while these medications are potent agents for shedding pounds, they are not a permanent cure and long-term success likely depends on integrated lifestyle support.
